Epidemiology
A benign myofibroblastic tumor, most common in infants and children, though it also occurs in adults. A solitary lesion is usually managed conservatively, but multiple nodules change the initial workup and the follow-up.
Basic features
A solitary myofibroma usually appears as a firm, slow-growing nodule in the skin, subcutaneous tissue, or muscle, with a favorable course. In contrast, when multiple lesions appear in an infant or child it may be a multicentric infantile myofibromatosis, which can sometimes involve internal organs.
Usual treatment
A typical, stable solitary lesion is observed, and is removed when it causes symptoms, grows, or requires diagnostic confirmation. When there are multiple lesions in an infant or child, a timely evaluation by a pediatric specialist is recommended to rule out involvement of internal organs.
Outcomes and prognosis
Solitary lesions have a very good outlook. The multicentric form with organ involvement is more serious, and its workup and management are defined by the corresponding pediatric team.