Epidemiology
A high-grade variant of osteosarcoma that appears mostly in children, adolescents, and young adults. Because it can be mistaken for an aneurysmal bone cyst, a lesion that looks like a bone cyst but has atypical features is biopsied before being treated as one: the difference changes the treatment completely.
Basic features
It can look like an aneurysmal bone cyst because it shows blood-filled spaces and fluid-fluid levels on MRI.
Usual treatment
It is managed as a high-grade osteosarcoma with chemotherapy and wide resection when possible. Before chemotherapy starts it is worth discussing fertility preservation with the team, because some of these treatments can affect it and the options have to be raised beforehand.
Outcomes and prognosis
With modern treatment its results are comparable to those of conventional osteosarcoma if it is diagnosed and treated correctly.
