Dr. Francisco Bengoa
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Soft-tissue tumors

CIC-rearranged sarcoma

Soft tissueMalignant / sarcomaUndifferentiated small round cell sarcomas

Epidemiology

A rare molecular sarcoma, more common in adolescents and young adults, that usually arises in deep soft tissue. It can look like Ewing sarcoma, but it usually has a distinct biology; molecular tests are needed to name it correctly.

Basic features

It can look like Ewing sarcoma, but it has different genetics and behavior.

Usual treatment

It is managed at sarcoma centers with chemotherapy, surgery, and radiotherapy depending on extent and response. Before chemotherapy starts it is worth discussing fertility preservation with the team, because some of these treatments can affect it and the options have to be raised beforehand.

Outcomes and prognosis

It tends to be aggressive, with a more guarded prognosis than Ewing sarcoma; follow-up looks for early recurrence and metastases.

Warning signs

These signs do not necessarily mean cancer, but they warrant evaluation before operating on or needling a mass.

  • A soft-tissue mass that grows, is larger than 5 cm, or is deep.
  • Persistent, night-time or progressive bone pain, especially if it limits activity.
  • A fracture from minimal trauma, or an aggressive bone lesion on an X-ray.
  • A lump that comes back after previous surgery.
  • Neurological symptoms, rapid swelling, or pain associated with a mass.

This information is general and does not replace a medical evaluation. A musculoskeletal tumor must be interpreted together with imaging, physical examination, biopsy when appropriate and each patient's context.

Specialist evaluation

If you have a mass, a bone lesion or a report suggesting a tumor, book an evaluation.

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